AH39 Next-Gen Gut Health | AH39 Next-Gen Gut Health
AH39 Next-Gen Gut Health | AH39 Next-Gen Gut Health
AH39 Next-Gen Gut Health | AH39 Next-Gen Gut Health
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AH39 Next-Gen Gut Health | AH39 Next-Gen Gut Health

$1,880.00
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Cell-Wall Disruption for Precision Extraction (The Hammer Effect)

Live AKK is highly unstable and easily destroyed by stomach acid. Our "walnut-cracking" pasteurization technology (The Hammer Effect) breaks open the cell wall like cracking a walnut, fully releasing the hidden Amuc_1100 core protein for maximum bioavailability and absolute safety.

Core Scientific Advantage (Tri-Core Advantage)

Naturally boosts GLP-1
AH39 secretes the P9 peptide, precisely targeting gut L-cells to trigger release of the satiety hormone GLP-1 — no injections needed.

High-concentration Amuc_1100
Directly activates the TLR2 receptor and induces the IL-10 anti-inflammatory factor to rapidly rebalance the immune system.

Asia-exclusive formula
Isolated from over 10,000 healthy Asian human samples and hand-selected against more than 200 native strains.

Dosage & Timeline

How to use:
Daily maintenance (1 capsule/day) / Weight management (2 capsules/day). Take on an empty stomach with warm water 15–30 minutes before breakfast.

Results timeline:
Weeks 1–4 (gut adaptation) ➜ Weeks 4–8 (metabolic activation) ➜ Week 8–12 and beyond (visible drop in body shape and fat ratio).

    Powered by AH39 (Akkermansia), this next-generation postbiotic is designed to fortify your gut barrier and recharge your metabolism. We use a specialized process to unlock the full potential of the bacteria, ensuring maximum effectiveness for your body.

    Powered by AH39 (Akkermansia) and built to fortify your gut barrier and restart your metabolism. Our specialized process unlocks the strain's full potential, ensuring your body achieves the most effective absorption and action.

    30 Billion Cells Per Serving
    30 Billion Active Units Per Serving

    A synergistic blend of AH39, HP59, CCFM0528, Prebiotics (XOS), and Green Tea Polyphenols to support gut barrier integrity, immune resilience, and metabolic homeostasis.

    A synergistic blend of AH39, HP59, CCFM0528, prebiotics (XOS) and green tea polyphenols, this formula is designed to support gut barrier integrity, immune resilience and metabolic homeostasis.
    -2.27kg body weight
    -1.37kg body fat
    -2.63cm hip circumference
    Lower LDL cholesterol
    Proven in a 12-week double-blind RCT
    -2.27kg body weight
    -1.37kg body fat
    -2.63cm hip circumference
    Lower LDL cholesterol
    Proven in a 12-week double-blind RCT
    -2.27kg body weight
    -1.37kg body fat
    -2.63cm hip circumference
    Lower LDL cholesterol
    Proven in a 12-week double-blind RCT
    -2.27kg body weight
    -1.37kg body fat
    -2.63cm hip circumference
    Lower LDL cholesterol
    Proven in a 12-week double-blind RCT
    -2.27kg body weight
    -1.37kg body fat
    -2.63cm hip circumference
    Lower LDL cholesterol
    Proven in a 12-week double-blind RCT
    -2.27kg body weight
    -1.37kg body fat
    -2.63cm hip circumference
    Lower LDL cholesterol
    Proven in a 12-week double-blind RCT
    Validated by leading medical journals

    12-Week Double-Blind Clinical Validation | Clinical Validation

    Depommier et al., Nature Medicine 2019 (NCT02637115); Zhang et al., Cell Metabolism 2025 (Asian-population clinical trial).
    MECHANISM OF ACTION

    Four key metabolic pathways activated at once

    ① Stimulates GLP-1 secretion

    The P9 protein activates intestinal L-cells through CXCR3 / GPR41-43, mimicking a "natural" semaglutide mechanism — triggering the release of satiety hormones with no injections required.

    ② Activates AMPK and FIAF

    Boosts fatty-acid oxidation in the liver and fat tissue, reduces fat storage, and regulates energy metabolism at its source.

    ③ Repair the gut mucosal barrier

    Amuc_1100 thickens the gut mucus layer, reducing LPS leakage and chronic metabolic endotoxemia.

    ④ Improve insulin sensitivity

    Activates the TLR2 receptor via Amuc_1100 to restore blood-sugar balance and improve insulin resistance.
    BEYOND WEIGHT

    More than weight: AKK is a key regulator of immunity

    Research in top-tier journals shows that under PD-1 immunotherapy, Akk⁺ patients gained up to 40% longer survival (18.8 vs 13.4 months). AH39 comprehensively balances the immune system by inducing the IL-10 anti-inflammatory factor and Treg cells.

    Clinical applications span IBD / IBS, allergy modulation, periodontitis and immunotherapy support.

    PASTEURIZATION ADVANTAGE

    Counterintuitive, yet proven in Nature Medicine.

    Live AKK

    ✕ Unstable at room temperature and prone to losing activity
    ✕ Requires cold-chain shipping with high logistics costs
    ✕ Loses potency throughout its shelf life
    ✕ Hard to reach a safe effective dose in key RCTs
    ✕ Poses an infection risk for immunocompromised individuals

    Pasteurized AH39 ★

    ✓ Significantly elevated Amuc_1100 protein levels with effective TLR2 binding
    ✓ Statistically significant improvements across every measure — weight, fat, LPS and insulin resistance
    ✓ Stable at room temperature for 24 months (25°C / 60% RH)
    ✓ Safer, with no risk of infection
    ✓ Suitable for pregnant women, children and the immunocompromised
    THE AH39 ADVANTAGE

    Why AH39 is the smarter choice

    ① Premium Strains

    9 years in development, FDA sGRAS certified, and nationally patented — the world's first P9-protein strain (99.87% similarity to BAA-835).

    ② Dual-Action, Proven

    Dual clinical validation across weight management (GLP-1, fat oxidation) and immune regulation (Treg, IL-10).

    ③ The pasteurization advantage

    Proven in Nature Medicine: stable at room temperature for 24 months — safe to ship and more effective than live bacteria.

    ④ All-in-One Platform

    More than a single strain — a triple synergistic formula pairing AH39 with L. plantarum and L. rhamnosus.

    ⑤ Clinical Endorsement

    Co-developed with Hong Kong licensed physicians — the only clinically adopted AKK brand in Hong Kong.
    Next-Generation Gut Health
    Gut Repair
    Metabolic Activation
    Clinical Research
    Next-Generation Gut Health
    Gut Repair
    Metabolic Activation
    Clinical Research
    Next-Generation Gut Health
    Gut Repair
    Metabolic Activation
    Clinical Research
    Next-Generation Gut Health
    Gut Repair
    Metabolic Activation
    Clinical Research
    Next-Generation Gut Health
    Gut Repair
    Metabolic Activation
    Clinical Research
    Next-Generation Gut Health
    Gut Repair
    Metabolic Activation
    Clinical Research
    Our Philosophy

    smart science for better health

    nubu harnesses cutting-edge artificial intelligence (AI) to transform data into answers for health and longevity. Utilizing a database specifically tailored for Hong Kong residents, we deliver precision health solutions—from meticulous lifestyle adjustments to targeted nutritional supplement recommendations—each uniquely customized to individual needs. By empowering users with clarity over their personal health and precision in health management, we optimize every step in safeguarding wellbeing.

    nubu harnesses cutting-edge AI-driven health to turn your data into answers for a longer, healthier life. Built on a database made exclusively for Hong Kongers, we deliver precision-health plans — from the subtlest lifestyle adjustments to exact supplement recommendations — each uniquely tailored to you. With clearer insight into your own health and pinpoint precision in managing it, every step toward protecting your wellbeing is optimized.